TEST CATALOG ORDERING & RESULTS SPECIMEN HANDLING CUSTOMER SERVICE EDUCATION & INSIGHTS
Test Catalog

Test ID: MPCDS    
mSMART, Plasma Cell Proliferative Disorder, FISH, Bone Marrow

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

This test is only orderable as part of a profile, based on the flow cytometric analysis and presence of 0.1% or greater monotypic plasma cells. For more information see MSMRT / Mayo Algorithmic Approach for Stratification of Myeloma and Risk-Adapted Therapy Report, Bone Marrow.

 

This test is designed for diagnostic specimens from patients with multiple myeloma or other plasma cell proliferative disorders.

 

This test includes a charge for application of the first probe set (2 fluorescence in situ hybridization: FISH probes) and professional interpretation of results. Additional charges will be incurred for all reflex probes performed. Analysis charges will be incurred based on the number of cells analyzed per probe set. If no cells are available for analysis, no analysis charges will be incurred.

 

For diagnostic samples, all probes in the initial panel will be evaluated if sufficient plasma cells are identified. The initial panel includes testing for the following abnormalities using the probes listed:

17p-, TP53/D17Z1

1q gain, TP73/1q22

14q32 rearrangement, IGH

t(11;14), CCND1/IGH

8q24.1 rearrangement, MYC

-13/13q-, RB1/LAMP1

+9/+15, D9Z1/D15Z4

+3/+7, D3Z1/D7Z1

Based on the results from the initial panel, reflex testing may be performed to identify the following abnormalities using the probes listed:

t(14;16)(q32;q23) IGH/MAF

t(4;14)(p16.3;q32) FGFR3/IGH

t(14;20)(q32;q12) IGH/MAFB

t(6;14)(p21;q32) CCND3/IGH

 

For follow-up samples, only TP73/1q22, TP53/D17Z1 and MYC probes along with a single probe that was abnormal in a previous study will be tested. If a previous sample was uninformative due to an insufficient number of plasma cells, analysis will begin with the initial panel (if sufficient plasma cells are identified).

 

Initial screening will be performed to determine if sufficient plasma cells are present within the provided specimen. If the standard algorithm is not desired, indicate which probes should be used.

Specimen Type Describes the specimen type validated for testing

Bone Marrow

Specimen Required Defines the optimal specimen required to perform the test and the preferred volume to complete testing

Only orderable as part of a profile. For more information see MSMRT / Mayo Algorithmic Approach for Stratification of Myeloma and Risk-Adapted Therapy Report, Bone Marrow.

Specimen Minimum Volume Defines the amount of sample necessary to provide a clinically relevant result as determined by the Testing Laboratory

2 mL

Reject Due To Identifies specimen types and conditions that may cause the specimen to be rejected

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included

Specimen TypeTemperatureTimeSpecial Container
Bone MarrowAmbient (preferred)
 Refrigerated